In 1995, Regina Shavers co-founded GRIOT Circle to combat the lack of community that she had observed amongst LGBT Elders, particularly those of color. Since then, GRIOT Circle has become "an intergenerational and culturally diverse community-based social service organization responsive to the realities of older lesbians, gay men, bisexuals, two-spirit and transgender people (LGBTST) of all colors.” In 2000, Regina assumed the role of Executive Director of GRIOT.

Regina had a long history of community involvement and activism. As co-chair of District Council 37, she advocated for workers’ rights and served on the American Federation of State, County, and Municipal Employees (AFSCME) Lesbian and Gay Rights Advisory Board. She played an active role in the Campaign for Inclusive Family Policy, the citywide coalition that obtained domestic partner benefits for New York City employees, and also helped to found Pride At Work, a constituency group of the AFL-CIO that focuses on the rights and unionization of LGBT workers.

The former Assistant Director of the NYC Department of Health’s HIV Training Institute, Regina created and implemented curricula for HIV prevention and treatment, including education tailored for older populations. Regina continued with her HIV/AIDS facilitation as a member of the New York Association on HIV Over Fifty (NYAHOF).